Expression pattern of CK7, CK20, CDX-2, and villin in intestinal-type sinonasal adenocarcinoma
نویسندگان
چکیده
منابع مشابه
Expression pattern of CK7, CK20, CDX-2, and villin in intestinal-type sinonasal adenocarcinoma.
BACKGROUND Intestinal-type sinonasal adenocarcinoma (ITAC) is an uncommon neoplasm, which resembles adenocarcinoma of the gastrointestinal tract. ITAC occurs sporadically or in association with occupational exposure to hardwood dust and other agents. AIMS To investigate the phenotype and possible pathogenetic mechanisms of primary sinonasal and nasopharyngeal adenocarcinomas by staining for c...
متن کاملPrimary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature
BACKGROUND Primary adenocarcinoma of thymus is extremely rare. CASE PRESENTATION This is a case of primary adenocarcinoma with intestinal differentiation and focal mucin production in the thymus. Thymic cyst was associated with this tumor. Intestinal differentiation was confirmed by immunohistochemical stain with positivity for CDX-2, CK20, villin, MOC31 and focal positivity of CK7. Array com...
متن کاملBenign Lesions in Mucosa Adjacent to Intestinal-Type Sinonasal Adenocarcinoma
Occupational exposure to wood dust is a strong risk factor for the development of intestinal-type sinonasal adenocarcinoma (ITAC); however, knowledge on possible precursor lesions or biomarkers is limited. Fifty-one samples of tumor-adjacent mucosa and 19 control samples of mucosa from the unaffected fossa of ITAC patients were evaluated for histological changes and p53 protein expression. Mild...
متن کاملExpression of mismatch repair proteins, b catenin, and E cadherin in intestinal-type sinonasal adenocarcinoma
Background: Despite their histological resemblance to colorectal adenocarcinomas, there is little information about the molecular events involved in the pathogenesis of intestinal-type sinonasal adenocarcinomas (ITACs). Aims: To evaluate the possible role of DNA mismatch repair (MMR) gene defects or disruptions of the E cadherin–b catenin complex in ITAC by investigating the immunohistochemical...
متن کاملExpression of mismatch repair proteins, beta catenin, and E cadherin in intestinal-type sinonasal adenocarcinoma.
BACKGROUND Despite their histological resemblance to colorectal adenocarcinomas, there is little information about the molecular events involved in the pathogenesis of intestinal-type sinonasal adenocarcinomas (ITACs). AIMS To evaluate the possible role of DNA mismatch repair (MMR) gene defects or disruptions of the E cadherin-beta catenin complex in ITAC by investigating the immunohistochemi...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 2004
ISSN: 0021-9746
DOI: 10.1136/jcp.2004.016964